Abwiz Bio Inc

Biotechnology ResearchCalifornia, United States2-10 Employees

Abwiz Bio is a San Diego-based antibody CRO specializing in rabbit monoclonal antibodies against difficult targets. Since 2012, we have helped pharmaceutical and biotech companies generate high-affinity antibodies for GPCRs, ion channels, multi-pass membrane proteins, and other targets where conventional mouse platforms fail.

Why Pharma Partners Choose Abwiz Bio:

We solve the targets others can't. When your mouse antibody campaign delivers only low-affinity binders — or none at all — our rabbit phage display platform consistently delivers picomolar-affinity antibodies that recognize conformational epitopes on challenging human antigens.

Proprietary Technology Platform:
- WizAmp™: Unbiased, high-diversity antibody library construction from immunized rabbits
- RabWiz™: Optimized phage display system for rabbit CK1 light chains, yielding 10-100x more unique clones than competitors
- STEM™: Proprietary affinity maturation and humanization technology for clinical-stage developability

Proven Track Record:
- Successfully generated antibodies against GPCR and ion channel targets after other CROs failed
- Achieved 10-fold affinity improvement via STEM™ maturation (demonstrated on SARS-CoV-2 program)
- U.S. patent 9,890,414 covering our phage display library technology
- 100% in-house operations from immunization to IgG purification — no outsourcing, full IP control

Services:
- Custom rabbit monoclonal antibody generation
- Antibody engineering and optimization
- Humanization for therapeutic applications
- Affinity maturation using STEM™ technology

All work is performed in our San Diego facility. We deliver purified IgG candidates with full sequence data, ready for your downstream characterization.

Contact us to discuss your next difficult target.

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