Affinia Therapeutics
Biotechnology ResearchMassachusetts, United States51-200 Employees
We are a team with decades of proven success in translating science from bench to bedside across many companies and medicines, in gene therapy and beyond. We are driven by a purpose: to make a lasting positive impact in the lives of people affected by devastating rare and prevalent diseases where the genetic cause is understood. Our thesis is simple and our vision, clear: gene therapies have an immense potential to cure many diseases with a one-time dose, but they are limited by current delivery methods for the genetic payload. We formed Affinia Therapeutics to singularly focus on creating innovations that can expand the reach of gene therapies to more prevalent diseases. We're re-engineering adeno-associated virus serotype 9 (AAV9), a gene therapy delivery method that has shown promise but only in a small number of diseases. At Affinia Therapeutics, we call it ART: Affinia Rationally-designed Therapies. ART can benefit any tissue of interest such as the eye, heart, kidney, liver, lung, muscle, nervous system, or pancreas. We use AI, structural modeling, and other cutting-edge scientific tools to methodically re-design AAV9, enabling it to better target tissues and cells that are the desired sites of efficacy while avoiding sites of toxicity. Our goal is genetic medicines that can be given as a one-time dose to effectively and safely correct defective genes in the body – the underlying root cause of many diseases. We dream of using the word “cure.” As an early team member you will play a key role in setting our culture and values. You will be working alongside the founding management team who have a track record of success in the industry. The pace of work is dynamic, fast and fun. Our site includes: State of the Art lab space & Equipment- Healthy Cafe, Outdoor Patio, State of the Art Gym/Yoga Studio, Lounge ( Pool Table/ Golf Simulator ), Free/Plentiful Parking and More! Join Us!