Against The Grain
Food and Beverage ServicesKentucky, United States51-200 Employees
Against The Grain is a mid-sized craft brewery and smokehouse based in Louisville, Kentucky. It was founded in 2011 as Louisville’s first brewer-owned and operated brewery, operating a 15-barrel Victorian-style brewhouse with a Southern-inspired smokehouse. The brewery produces a varied lineup of beers categorized into six main styles—Session, Hop, Whim, Malt, Dark, and Smoke. In addition to brewing, the company operates a smokehouse, combining beer production with food service. The downtown facility is located at 401 East Main Street, Louisville, Kentucky 40202. In November 2025, reports indicated that the Bardstown Road location had closed, with plans for the downtown site to follow by the end of 2025.