Biosplice Therapeutics
Biotechnology ResearchCalifornia, United States11-50 Employees
Biosplice is developing lorecivivint (LOR) for the treatment of knee osteoarthritis. Lorecivivint is a small-molecule suspension drug intended to be injected into the intra-articular knee joint space for the treatment of OA. LOR has been tested as a once-per-year or every-six-month injection in Biosplice’s development program. LOR’s mechanism of action is based on selective and potent inhibition DYRK1A and CLK2 kinases. DYRK1A inhibition has been shown to reduce inflammation and catabolic enzymes, and inhibition of CLK2 is believed to provide cartilage protective and regenerative properties. The extensive clinical development program for LOR has provided evidence for statistically and clinically significant improvement in pain, function and medial JSW with a very good safety profile. LOR has not yet been approved by the FDA. Learn more at https://www.biosplice.com Through it's affiliate TenaRx, Inc., Biosplice is also developing treatments for diabetes, oncology and neurology. Learn more at www.tenarx.com