Circle Pharma, Inc. Email Format

Biotechnology ResearchCalifornia, United States51-200 Employees

Circle Pharma, Inc. develops macrocyclic peptide therapeutics aimed at intracellular cancer targets. The company employs a structure-based computational framework that integrates conformational modeling, chemical design, and protein target information to create drug candidates with cell permeability. Its initial focus is on intracellular protein–protein interactions that drive cancer, pursued through an internal pipeline and potential collaborations with partners. Based in South San Francisco, California, it has operated since 2014. Its workflow includes generating diverse virtual libraries of macrocyclic scaffolds, followed by synthesis and testing to assess permeability and target binding, with results guiding iterative design. In late 2025, Circle Pharma announced preclinical data from its Cyclin D1 program at a major cancer research conference, signaling progress in its development program.

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