Sierra Oncology
Biotechnology ResearchCalifornia, United States2-10 Employees
Based in San Mateo, California, Sierra Oncology is a late-stage biopharmaceutical company focused on developing targeted therapies for rare cancers. It leverages deep scientific expertise to identify compounds addressing root causes of disease and to advance cancer treatments at the forefront of biology. With a small, specialized team, the company pursues collaborations to move promising science toward patient impact. Momelotinib is the lead candidate, a selective inhibitor targeting JAK1, JAK2 and ACVR1 for myelofibrosis, a disorder driven by dysregulated JAK-STAT signaling. Its clinical program is in global Phase 3 MOMENTUM for symptomatic and anemic patients, and the FDA has granted Fast Track designation. The portfolio also includes SRA737, a Checkpoint kinase 1 inhibitor that has shown activity with low-dose gemcitabine and may have synergy with anti-PD-L1 therapies in preclinical studies.