Skye Bioscience Inc.
Biotechnology ResearchCalifornia, United States11-50 Employees
Skye Bioscience Inc. is a biotechnology research company focused on metabolic health, developing new molecules that modulate G-protein coupled receptors. The firm aims to deliver first-in-class therapies with distinct clinical and potential commercial advantages by pursuing biologic targets supported by human proof of mechanism. Based in San Diego, California, the company operates with a relatively small to mid-sized team and concentrates on obesity and related metabolic disorders. Its lead candidate nimacimab is a peripherally restricted antibody that inhibits CB1, and the company planned to initiate a Phase 2 trial in obesity in the third quarter of 2024, comparing monotherapy with a combination approach involving Wegovy, a GLP-1 receptor agonist. In January 2026 Skye announced a collaboration with Halozyme Therapeutics to explore higher-dose subcutaneous administration strategies for nimacimab.