Syntis Bio
Biotechnology ResearchMassachusetts, United States11-50 Employees
Syntis Bio is a clinical-stage biotechnology company that develops oral therapies designed to influence metabolism and nutrient absorption by targeting the small intestine. Its approach aims to deliver accessible, effective, and sustainable treatments across conditions, ranging from rare genetic disorders to common diseases. Based in Boston, Massachusetts, the company operates as a small-to-mid-sized organization focused on translating research into early to mid-stage therapeutic programs. The lead program, SYNT-101, is a daily tablet intended to mimic certain effects of gastric bypass surgery by delivering a transient coating to the duodenum that modulates nutrient uptake and supports enzyme activity and systemic drug absorption. In March 2026, Syntis Bio announced the appointment of David Rosenbaum as Chief Development Officer, signaling a formal expansion of its leadership as it advances its pipeline.