TearSolutions Inc. Employee Directory

Pharmaceutical ManufacturingVirginia, United States2-10 Employees

TearSolutions Inc. is a Delaware Corporation based in Charlottesville, VA.  The company has successfully completed a well-powered 204 patient Phase II Proof of Concept clinical trial for the treatment of ocular surface disease in primary Sjögren’s Syndrome patients. Statistically significant improvement in both sign and symptom at two weeks was found.  The trial compared vehicle and two doses of LacripepTM, a novel 19 AA peptide that is present in normal tears and deficient in all forms of dry eye.  The peptide restores homeostasis to the ocular surface, in particular the barrier function of the corneal epithelium and normal function of sensory nerves at the corneal surface in preclinical animal models.  Restoration of epithelial barrier function can be measured clinically as a decrease in corneal fluorescein staining while the improvement in sensory nerve function restores normal production of the components of tears: the aqueous via reinnervation of lacrimal glands, the lipid via reinnervation of meibomium glands and the mucin via reinnervation of goblet cells.  Improvement in fluorescein staining and tear production (Schirmer tear test) are clinical ‘signs’ of ocular suface disease that have been used in the FDA approval of Xiidra and Restasis, respectively.

Lacripep was discovered at the University of Virginia with NIH National Eye Institute funding as a naturally occurring fragment of the larger 119 AA protein, lacritin, in an unbiased screen for novel factors capable of addressing dry eye.

Management team
- CEO/President: Anil Asrani
- Executive Chair: Robert Dempsey
- CSO/Cofounder: Gordon W. Laurie PhD, FARVO
- CFO: Colin M. Rolph
- Chief Regulatory Officer: Michelle Carpenter JD, RAC
- Chief Medical Officer: Marc G. Odrich, MD
- Secretary: Mac Thompson, LLD

For more information please visit www.tearsolutions.com

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