Arch Oncology
Biotechnology ResearchCalifornia, United States11-50 Employees
Arch Oncology is a clinical-stage biotechnology company in the immuno-oncology space, focused on discovering and developing antibody therapies for solid tumors and hematologic malignancies, with AO-176 as its lead candidate in Phase 1/2 trials. The company maintains a pipeline of antibody programs targeting cancer, including next-generation anti-CD47 antibodies designed to offer improved safety and efficacy profiles. AO-176 blocks the don't eat me signal on macrophages and may also directly kill tumor cells and induce immunogenic cell death, with preferential binding to CD47 on tumor cells and greater activity in acidic tumor microenvironments. Arch Oncology is headquartered in Brisbane, California, and operates a scientific research laboratory in St. Louis, Missouri, with a headcount reported at 11-50 employees. In January 2023, media reports indicated the company stopped developing AO-176 and laid off all employees.