Taysha Gene Therapies
Biotechnology ResearchTexas, United States51-200 Employees
Taysha Gene Therapies is a clinical-stage biotechnology company based in Dallas, Texas, focused on developing adeno-associated virus–based gene therapies for severe monogenic diseases of the central nervous system. Its lead program, TSHA-102, is being developed for Rett syndrome, a rare neurodevelopmental disorder with no approved disease-modifying therapies addressing the genetic root cause. The company relies on the experience of its management in gene therapy development and commercialization and uses an AAV9 capsid that has been clinically and commercially validated to help translate research into potential treatments. Its work targets patients with Rett syndrome and other CNS monogenic diseases and the caregivers who support them, seeking to address significant unmet medical needs. In 2026, Taysha disclosed new preclinical data supporting the construct design of TSHA-102 for Rett syndrome at the ASGCT annual meeting.