NuCana plc
Biotechnology ResearchScotland, United Kingdom11-50 Employees
NuCana plc is a clinical-stage biotechnology company based in Edinburgh, Scotland, focused on improving cancer treatment outcomes. It employs a proprietary prodrug approach rooted in phosphoramidate chemistry to convert widely used chemotherapy agents into medicines that may deliver higher concentrations of active metabolites to cancer cells while addressing resistance and reducing toxicity. Its work targets patients with cancer and the clinicians who treat solid tumors within the context of standard care, aiming to enhance both effectiveness and tolerability. Operating in biotechnology research, NuCana pursues nucleotide analogue therapies and other ProTide-based candidates as part of its late-stage development program. In December 2025, NuCana disclosed phase 2 expansion data for NUC-7738 in combination with pembrolizumab at the ESMO Immuno-Oncology Congress, reflecting ongoing clinical activity.