Orna Therapeutics Email Format

Biotechnology ResearchMassachusetts, United States51-200 Employees

Orna Therapeutics is a mid-sized biotechnology company based in Watertown, Massachusetts. It is advancing RNA-based therapies by developing a circular RNA platform, known as oRNA, alongside new lipid nanoparticle delivery approaches to enable in vivo treatments for disease. The aim is to broaden the therapeutic potential of circular RNA and to support the development of safe, effective in vivo therapies.

In late 2025, the company reported preclinical data for its in vivo CAR programs targeting B cell–driven autoimmune diseases and BCMA-related conditions, presented at the ASH annual meeting. More recently, Orna disclosed the development of ORN-252, a program directed at the CD19 lymphocyte surface antigen for treating autoimmune diseases driven by B cells. These developments illustrate a concentrated effort on autoimmune indications and immune-cell–targeted approaches within its research portfolio.

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