Cofactor Genomics

Biotechnology ResearchMissouri, United States11-50 Employees

Cofactor Genomics is a biotechnology research company based in St. Louis, Missouri, focused on developing diagnostics to identify patients likely to benefit from immunotherapies. The company uses RNA-based multidimensional biomarkers and machine learning to characterize the tumor immune environment, aiming for predictive power beyond single-analyte biomarkers or DNA mutations. Its OncoPrism immunotherapy predictive diagnostic assay, launched in November 2023, is designed to guide treatment decisions for patients with metastatic or recurrent squamous cell carcinoma of the head and neck. Cofactor Genomics employs 11-50 people and is located at 4044 Clayton Avenue, St. Louis, MO 63110. The company has pursued external partnerships and leadership changes, including investments from Labcorp and Ascension Ventures in 2025 and the appointment of Chris Parker as CEO and board member in January 2025.

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