Synthekine Employee Directory

Biotechnology ResearchCalifornia, United States51-200 Employees

Synthekine is a biotechnology research company based in Menlo Park, California, at 1505 Obrien Drive Suite a, with 51-200 employees. The company develops engineered cytokine therapeutics for cancer and autoimmune diseases, applying immunological insights to guide targeted protein engineering, including partial agonism and immunological specificity to balance safety and efficacy. Its lead programs have shown promising efficacy and tolerability in preclinical studies, and it is pursuing additional cytokine partial agonists that selectively modulate key immune pathways. In 2025, Synthekine announced a PD-L1-negative program at the SITC annual meeting and presented initial clinical data for STK-012 in combination with pembrolizumab and chemotherapy in first-line, PD-L1-negative nonsquamous NSCLC. The company has established a worldwide collaboration with Sanofi to develop IL-10 receptor agonists for inflammatory diseases and has programs such as STK-026, an IL-12 partial agonist, and STK-009 plus SYNCAR-001, a CD19 CAR-T combination therapy.

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