Insights

Clinical momentum UpStream is advancing Verekitug with a clear path to Phase 3 in severe asthma and CRSwNP, backed by positive Phase 2 results and a Q1 2027 initiation window. Sales opportunities exist in partnering with payers and clinics early to secure access and reimbursement support around the upcoming pivotal trials.

Strategic partnerships The company combines in-practice support with advanced technology and new payment models, suggesting opportunities to position value-based care partnerships, digital health integrations, and reimbursement-friendly arrangements with hospital systems and primary care networks.

Financial footing With substantial funding and multi‑year clinical development plans, UpStream Bio demonstrates resilience for ongoing outreach to biotech funders, CROs, and potential collaborators, while presenting a credible partner for specialty pharmaceutical distributors focusing on respiratory therapies.

Evidence credibility Recent presentations showing significant improvements in nasal polyps and asthma outcomes provide a talking point for clinical education channels, key opinion leaders, and health system adoption discussions to accelerate trial enrollment and eventual market access.

Growth signaling Consistent media coverage of trial results and positive revisits to Phase 3 strategy indicate a rising market profile, presenting opportunities to engage regional accounts, academic medical centers, and payer networks seeking high‑impact respiratory disease therapies.

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UpStream Tech Stack

UpStream uses 8 technology products and services including LinkedIn Recruiter, Amazon Web Services, GitHub, and more. Explore UpStream's tech stack below.

Media & News

UpStream's Email Address Formats

UpStream uses at least 2 email formats:
UpStream Email FormatsExamplePercentage
First.Last@upstream.careJohn.Doe@upstream.care
98%
Last@upstream.careDoe@upstream.care
2%

Frequently Asked Questions

What is UpStream's stock symbol?

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UpStream is a publicly traded company; the company's stock symbol is UPB.

What is UpStream's official website and social media links?

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UpStream's official website is upstream.care and has social profiles on LinkedIn and Crunchbase.

How much revenue does UpStream generate?

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As of July 2026, UpStream's annual revenue is estimated to be $10M - $25M.

What is UpStream's NAICS code?

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UpStream's NAICS code is 62 - Health Care and Social Assistance.

How many employees does UpStream have currently?

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As of July 2026, UpStream has approximately 201 employees across 1 continents, including North America. Key team members include Senior Ctl: C. F., Senior Clinical Documentation Coder And Educator: M. Z. and Coordinating Registered Nurse: C. L. H. Explore UpStream's employee directory with LeadIQ.

What industry does UpStream belong to?

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UpStream operates in the Hospitals and Health Care industry.

What technology does UpStream use?

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UpStream's tech stack includes LinkedIn Recruiter, Amazon Web Services, GitHub, Microsoft SharePoint, Google Cloud, Atlassian Jira, ServiceNow and Adobe Creative Suite.

What is UpStream's email format?

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UpStream's email format typically follows the pattern of First.Last@upstream.care. Find more UpStream email formats with LeadIQ.

How much funding has UpStream raised to date?

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As of July 2026, UpStream has raised $185M in funding. The last funding round occurred on Dec 01, 2022 for $140M.

When was UpStream founded?

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UpStream was founded in 2018.
UpStream logo

UpStream

Hospitals and Health CareNorth Carolina, United States201-500 Employees

UpStream is a healthcare company focused on transforming primary care by prioritizing preventative measures and strengthening the physician–patient relationship. The organization blends in-practice support with technology and distinctive payment models to reduce avoidable suffering and improve access to high-quality care. Founded in 2018, UpStream operates within the hospitals and health care industry and is guided by values centered on independence, inclusion, and innovation as it works toward a more integrated, technology-enabled healthcare system. The company is based in Greensboro, North Carolina, and maintains a workforce described in general terms as mid-sized.

Section iconCompany Overview

Stock Symbol
UPB
NAICS Code
62 - Health Care and Social Assistance
Founded
2018
Employees
201-500

Section iconFunding & Financials

  • $185M

    UpStream has raised a total of $185M of funding over 2 rounds. Their latest funding round was raised on Dec 01, 2022 in the amount of $140M as a Series B.

  • $10M - $25M

    UpStream's revenue is estimated to be in the range of $10M - $25M

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